Bovine superoxide dismutase in Fanconi anaemia. Therapeutic trial in two patients

Bovine superoxide dismutase (SOD) (Peroxinorm, Grünenthal Stolberg) was injected intramuscularly or subcutaneously in a daily dose of 4 mg over a period of six weeks into two patients with Fanconi anaemia. The effects (measured by the decrease of chromosome aberrations in blood lymphocytes and the i...

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Bibliographic Details
Published inHuman genetics Vol. 70; no. 2; p. 181
Main Authors Izakovic, V, Strbáková, E, Kaiserová, E, Krizan, P
Format Journal Article
LanguageEnglish
Published Germany 01.06.1985
Subjects
Anemia, Aplastic - drug therapy
Animals
Cattle
Child
Chromosome Aberrations - drug effects
Clinical Trials as Topic
Fanconi Anemia - drug therapy
Fanconi Anemia - genetics
Female
Humans
Male
Superoxide Dismutase - therapeutic use
Time Factors
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Summary:Bovine superoxide dismutase (SOD) (Peroxinorm, Grünenthal Stolberg) was injected intramuscularly or subcutaneously in a daily dose of 4 mg over a period of six weeks into two patients with Fanconi anaemia. The effects (measured by the decrease of chromosome aberrations in blood lymphocytes and the increase in blood cells in venous blood) were evident but temporary. The hypothetical mode of action of SOD and the failure of a prolonged therapeutic effect are discussed.
ISSN:0340-6717
DOI:10.1007/BF00273079