Alanine/electron spin resonance dosimetry for FLASH radiotherapy

• Published in: Radiation physics and chemistry (Oxford, England : 1993) Vol. 225; p. 112113
• Main Authors: Gu, Runqiu, Wang, Jianlin, Wang, Pan, Mao, Xin, Lin, Binwei, Tan, Wanchao, Du, Xiaobo, Gao, Feng, Wang, Tingting
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2024
• Subjects: Alanine dosimeter; Dose measurement; FLASH radiotherapy; Dose measurement; FLASH radiotherapy; Alanine dosimeter
• ISSN: 0969-806X
• DOI: 10.1016/j.radphyschem.2024.112113

The purpose of this study is to systematically study and analyse the dose calibration and measurement of the alanine/electron spin resonance dosimetry system in FLASH radiotherapy. The dose calibration curve of the alanine dosimeter ranged from 0 to 50 Gy, and the best linear fit to the data shows a correlation coefficient close to 1. In the stability experiment, the preset irradiation values for the alanine dosimeter and radiochromic film were 14.34 Gy and 13.38 Gy, respectively, and the results of a stability experiment results showed that the alanine dosimeter exhibited superior stability, compared with radiochromic film, with a deviation of less than 1% in repeated measurements. The results of X-ray FLASH irradiation experiments on mice showed that the maximum standard errors of the alanine dosimeter between the measured results and the preset dose values were 4.57% (chest experiment) and 3.22% (abdomen experiment), whereas those for the radiochromic film were 6.03% (chest experiment) and 6.50% (abdomen experiment). Additionally, X-ray and electron-beam FLASH radiotherapy experiments on mice verified that the alanine dosimeter showed no dose-rate dependence and provided more accurate measurement results compared to the radiochromic film. •Alanine dosimeters show high stability and accuracy in FLASH radiotherapy dosimetry.•Calibration curves show strong linear correlation, ensuring reliable measurements.•Potential for alanine dosimeters to enhance precision in FLASH radiotherapy.•The FLASH radiotherapy experiments highlight the dose rate independence of the response of alanine dosimeters.