Preparation of New Perfluoroalkylated Carbamate Group-containing Glycoside-based Nonionic Surfactants

The present work describes the synthesis of new perfluoroalkylated carbamate group-containing glycoside-based nonionic surfactants usable as co-surfactants for stabilizing injectable oxygen-carriers PFC emulsions and as potential antithrombotic agents. The key steps of the synthetic route converting...

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Bibliographic Details
Published inTenside Surfactants Detergents Vol. 44; no. 2; pp. 116 - 120
Main Authors Trabelsi, H., Nasreddine, M., Dieng, S. Y., Szönyi, S.
Format Journal Article
LanguageEnglish
Published De Gruyter 01.04.2007
Subjects
biomedical applications
biomedizinische Anwendungen
Glycosid
glycoside
nichtionisches Tensid
nonionic surfactant
Perfluoroalkyl group
Perfluoroalkylgruppe
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Summary:The present work describes the synthesis of new perfluoroalkylated carbamate group-containing glycoside-based nonionic surfactants usable as co-surfactants for stabilizing injectable oxygen-carriers PFC emulsions and as potential antithrombotic agents. The key steps of the synthetic route converting F-alkyl oxoesters into new F-alkyl glycosides are: formolysis, conversion to the respective acid chloride, isocyanate formation and glycosidation. The perfluoroalkyl group is connected through a carbamate function to 6-position of the sugar ring, and the glycosidation is performed from unprotected sugar.
ISSN:0932-3414
2195-8564
DOI:10.3139/113.100333