Case Report: Meningioma with Granulofilamentous Inclusions

• Published in: Ultrastructural pathology Vol. 24; no. 4; pp. 267 - 271
• Main Author: Hidehisa Horiguchi, Takanori Hirose, Toshiaki Sano, Shinji Nagahiro, Kunihiko Seki, Naomi Fujimoto, Fumihito Kaneko, Kazumasa Kusaka
• Format: Journal Article
• Language: English
• Published: Informa UK Ltd 2000; Taylor & Francis
• Subjects: Confocal Laser Microscopy Granulofilamentous Inclusions Meningioma Vimentin
• ISSN: 0191-3123; 1521-0758
• DOI: 10.1080/01913120050176725

The authors report a case of intracranial meningioma with granulofilamentous inclusions. A 50-year-old man had right trigeminal neuralgia due to trigeminal nerve compression by a petroclival tumor and received tumor resection. Microscopically, tumor cells containing eccentric nuclei and intracytoplasmic hyaline inclusions were arranged in sheets and whorls. The inclusions were negative for periodic acid-Schiff reaction. No histological anaplasia was seen. Immunohistochemistry showed epithelial membrane antigen reactivity on the cytoplasmic membrane. Immunoreactivity for vimentin was recognized in cytoplasm adjacent to inclusions. However, confocal laser microscopic study revealed immunoreactivity for vimentin even inside some inclusions. Ultrastructurally, interdigitation of cytoplasmic processes and desmosomes connecting adjacent cells were noted. Inclusions were composed of numerous fine osmiophilic granules attached by intermediates filaments. These findings were consistent with a meningioma with the granulofilamentous inclusions described earlier. The findings demonstrated by confocal laser microscopy and electron microscopy suggest that these granular materials may be the metabolic products of vimentin filaments.