N-PHENYL-N,N''-GUANIDINEDICARBOXYLIC ACID-ESTERS - SYNTHESIS, ANTHELMINTIC AND PESTICIDAL EFFECTS

Substituted phenylammonium chlorides react with cyanamide to give the corresponding phenylguanidines which on treatment with chloroformate esters give N-subst.phenyl-N,N''-guanidinedicarboxylic acid esters, All substances prepared have been tested for their anthelmintic activity against th...

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Bibliographic Details
Published inCollection of Czechoslovak chemical communications Vol. 57; no. 5; pp. 1127 - 1133
Main Authors PALAT, K, CELADNIK, M, DANEK, J, VARKONDA, S
Format Journal Article
LanguageEnglish
Published PRAGUE 6 Inst Organic Chem And Biochem 01.05.1992
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:Substituted phenylammonium chlorides react with cyanamide to give the corresponding phenylguanidines which on treatment with chloroformate esters give N-subst.phenyl-N,N''-guanidinedicarboxylic acid esters, All substances prepared have been tested for their anthelmintic activity against the model helminths Nippostrongylus brasiliensis and Hymenolepis nana var. fraterna. The most significant activity has been found with diethyl N-(4-nitrophenyl)-N,N''-guanidinedicarboxylate. in pesticidal screening the compounds have shown fungicidal activity and particularly ovicidal activity against Tetranychus urticae which activity is increased with the compounds having a nitro group in the benzene ring.
ISSN:0010-0765
1212-6950
DOI:10.1135/cccc19921127