The Effects of Minocycline Hydrochloride on a Juvenile Periodontitis Patient

• Published in: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 35; no. 1; pp. 219 - 228
• Main Authors: SUEDA, Takeshi, KANDA, Chieko, TANIGUCHI, Takuro, TAJIMA, Miyuki, CHUMAN, Masahiko, HARADA, Eiko, IZUMI, Yuichi, ONO, Tomonori, SHIBATATE, Kyoko, ETOGUCHI, Takashi
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY OF PERIODONTOLOGY 1993
• Subjects: Juvenile periodontitis; Local application; Minocycline hydrochloride
• ISSN: 0385-0110; 1880-408X
• DOI: 10.2329/perio.35.219

The purpose of this case study was to evaluate the effect of local application of minocycline hydrochloride as part of thetreatment regimen of a juvenile periodontitis patient. Experimental sites were classified into four groups: tooth brushing instruction only (T.B.I.), local application of minocycline hydrochloride (M), scaling and local application of minocycline hydrochloride (Sc+M) and only scaling (Sc). On clinical examinations, there were no significant differences among the four groups. On microbiological tests, theSc+M group showed that the total number of bacteria was significantly decreased, Spirochaetes were uncountable and Black-pigmented Bacteroides species and Actinobacillus actinomycetemcomitans were not isolated in culture, whereas Sc and M groups showed no significant differences as compared to the first visit. These results suggest that the local application of minocycline hydrochloride combined with debridement may be effective in the treatment of juvenile periodontitis patients.