Optic neuropathy following COVID-19 vaccine

ABSTRACT This case series describes four patients who presented with retinal and optic nerve vascular occlusions after administration of different COVID-19 vaccines. The first patient received the ChAdOx1 nCoV-19 vaccine (AZD1222; Oxford/AstraZeneca) and 42 days later developed central retinal arter...

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Published inRevista Brasileira de Oftalmologia Vol. 83
Main Authors Guareschi, Bianca Luiza Valduga, Geara, Amanda, Russ, Heloísa Helena Abil, Moraes, João Guilherme Oliveira de, Sato, Mario Teruo, Moore, Bret Alan, Ferreira, Fabiano Montiani
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Oftalmologia 19.06.2024
Subjects
COVID-19
COVID-19 vaccines
Drug-related side effects and adverse reactions
Retinal artery occlusion
Thromboembolism
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Summary:ABSTRACT This case series describes four patients who presented with retinal and optic nerve vascular occlusions after administration of different COVID-19 vaccines. The first patient received the ChAdOx1 nCoV-19 vaccine (AZD1222; Oxford/AstraZeneca) and 42 days later developed central retinal artery occlusion. The second patient developed a painless visual impairment in the left eye and was diagnosed with anterior ischemic optic neuropathy 6 days after receiving the Sinovac-CoronaVac vaccine. The third patient presented with the same condition 22 days after receiving the third dose of the COVID-19 Pfizer (Comirnaty®) vaccine. The fourth patient developed bilateral retrobulbar optic neuritis after receiving the Oxford/AstraZeneca vaccine. The purpose of this case series is to discuss the possibility of a causal association between ischemic eye alterations and COVID-19 virus vaccination. Long-term follow-up and evaluation of similar cases will help elucidate the degree of the association between the vaccine and ischemic ocular events.
ISSN:0034-7280
1982-8551
DOI:10.37039/1982.8551.20240033