The Changes in the Laboratory Values During Administration of Commercially Available Ready-to-use Basal Solutions for Total Parenteral Nutrition

• Published in: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) Vol. 27; no. 1; pp. 33 - 40
• Main Authors: Kimura, Yasuhiro, Sato, Eiji, Kihira, Kenji, Kitaura, Teruaki, Fukuchi, Hiroshi, Miyake, Katsushi, Arai, Shigeaki, Sakai, Masahiko, Ikeda, Hiroaki
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 2001
• Subjects: blood urea nitrogen; chloride ion; clinical laboratory values; commercially available ready-to-use basal solution
• ISSN: 1346-342X; 1882-1499
• DOI: 10.5649/jjphcs.27.33

Some differences are seen in the concentrations of glucose and electrolytes between commercially available ready-to-use basal solutions for total parenteral nutrition (R-TPN). In this study, we investigated the effects of the long-term administration of Unicaliq®, which contains relatively higher concentrations of chloride ions than other R-TPNs, on the clinical laboratory values. One hundred and nineteen patients, who received Unicaliq® for more than four weeks at Hiroshima University Hospital, participated in this study. The laboratory values of chloride ion (Cl-) and blood urea nitrogen (BUN) significantly increased after receiving Unicaliq® for 2 weeks, but all levels, except for BUN, returned to the pretreatment levels after 4 weeks of administration. However, these changes were slight and all were within the normal ranges. No changes were observed in other laboratory values during the 4-week administration period. These results suggest that the clinical laboratory values are not affected by the long-term administration of Unicaliq®, at least up until 4 weeks.