Inside Cover: Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes (ChemMedChem 4/2010)

The inside cover picture shows the design concept behind the antitumor and immunomodulatory phthalimides bio-inspired by thalidomide (top). Their immunosuppressor activity is derived from their ability to maintain low IL-10 production and suppress NO, with the advantage of not affecting the immune r...

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Published inChemMedChem Vol. 5; no. 4; p. 486
Main Authors Pessoa, Claudia, Ferreira, Paulo Michel P., Lotufo, Letícia Veras C., de Moraes, Manoel O., Cavalcanti, Suellen M. T., Coêlho, Lucas Cunha D., Hernandes, Marcelo Z., Leite, Ana Cristina L., De Simone, Carlos A., Costa, Vlaudia M. A., Souza, Valdênia M. O.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 06.04.2010
Subjects
antitumor agents
hydrazones
immunomodulation
molecular hybridization
phthalimides
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Summary:The inside cover picture shows the design concept behind the antitumor and immunomodulatory phthalimides bio-inspired by thalidomide (top). Their immunosuppressor activity is derived from their ability to maintain low IL-10 production and suppress NO, with the advantage of not affecting the immune response elicited by T-lymphocytes. Phthalimide 2 b (bottom) is as strongly active against solid sarcoma as thalidomide. For more details, see the Communication by A. C. L. Leite et al. on p. 523 ff.
Bibliography:ark:/67375/WNG-8NDPMPS6-M
istex:E2B170B867B1D33C44773A02303767D5A50E928F
ArticleID:CMDC201090011
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201090011