The Role of Recombinant Glycodelin in the Differentiation of Regulatory T-Lymphocytes

The effect of recombinant glycodelin (GdA) on the number of T-regulatory lymphocytes (Treg) in a culture of activated CD4 + lymphocytes was investigated, while simultaneously assessing the proliferative status of the cells. Recombinant GdA from E. coli and from HEK293 cells were used in the study at...

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Published inDoklady. Biological sciences Vol. 506; no. 1; pp. 137 - 140
Main Authors Shardina, K. Yu, Timganova, V. P., Bochkova, M. S., Khramtsov, P. V., Rayev, M. B., Zamorina, S. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2022
Springer Nature B.V
Subjects
Biomedical and Life Sciences
CD25 antigen
CD4 antigen
Cell culture
Evolutionary Biology
Life Sciences
Lymphocytes T
Plant Sciences
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Summary:The effect of recombinant glycodelin (GdA) on the number of T-regulatory lymphocytes (Treg) in a culture of activated CD4 + lymphocytes was investigated, while simultaneously assessing the proliferative status of the cells. Recombinant GdA from E. coli and from HEK293 cells were used in the study at concentrations of 0.2; 2 and 10 µg/mL. It was found that only a low concentration (0.2 μg/mL) of recombinant GdA of bacterial origin reduced the number of proliferating CD4 + lymphocytes as well as the number of Treg (CD4 + CD25 high CD127 -/low ) in the experimental system in vitro.
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ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496622050131