Fulminant hepatitis B
Fulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in synthesizing capacity of liver, and develops within eight weeks of the onset of hepatitis. Several independent factors influence the...
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| Published in | Vojnosanitetski pregled Vol. 60; no. 3; pp. 353 - 360 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Serbian |
| Published |
Serbia
Military Health Department, Ministry of Defance, Serbia
01.05.2003
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Fulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in synthesizing capacity of liver, and develops within eight weeks of the onset of hepatitis. Several independent factors influence the survival of patients: age, the cause of liver disease, the degree and the duration of encephalopathy in relation to the onset of the disease, and the prevention of complications. Over the years many intensive treatments have been practiced. Liver transplantation is expensive, and patients who survive transplantation require life-long immunosuppression, clinical care and complications management. Without transplantation fulminant hepatitis and hepatic failure might be completely recovered spontaneously, and the patient could expect a normal life. Two cases of fulminant B hepatitis with intensive care treatment, and their survival despite unfavorable prognosis are presented in this paper. The management of patients with fulminant hepatitis required intensive monitoring and therapeutic measures, including corticosteroids. The prognosis for survival without transplantation in fulminant hepatitis is limited by the measures of medical treatment and new specific therapeutic modalities which must be developed through basic research. |
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| AbstractList | Fulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in synthesizing capacity of liver, and develops within eight weeks of the onset of hepatitis. Several independent factors influence the survival of patients: age, the cause of liver disease, the degree and the duration of encephalopathy in relation to the onset of the disease, and the prevention of complications. Over the years many intensive treatments have been practiced. Liver transplantation is expensive, and patients who survive transplantation require life-long immunosuppression, clinical care and complications management. Without transplantation fulminant hepatitis and hepatic failure might be completely recovered spontaneously, and the patient could expect a normal life. Two cases of fulminant B hepatitis with intensive care treatment, and their survival despite unfavorable prognosis are presented in this paper. The management of patients with fulminant hepatitis required intensive monitoring and therapeutic measures, including corticosteroids. The prognosis for survival without transplantation in fulminant hepatitis is limited by the measures of medical treatment and new specific therapeutic modalities which must be developed through basic research. Fulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in synthesizing capacity of liver, and develops within eight weeks of the onset of hepatitis. Several independent factors influence the survival of patients: age, the cause of liver disease, the degree and the duration of encephalopathy in relation to the onset of the disease, and the prevention of complications. Over the years many intensive treatments have been practiced. Liver transplantation is expensive, and patients who survive transplantation require life-long immunosupression, clinical care and complications management. Without transplantation fulminant hepatitis and hepatic failure might be completely recovered spontaneously, and the patient could expect a normal life. Two cases of fulminant B hepatitis with intensive care treatment, and their survival despite unfavorable prognosis are presented in this paper. The menagement of patients with fulminant hepatitis required intensive monitoring and therapeutic measures, including corticosteroids. The prognosis for survival without transplantation in fulminant hepatitis is limited by the measures of medical treatment and new specific therapeutic modalities which must be developed through basic research. Fulminant hepatitis, or fulminant hepatic failure, is defined as a clinical syndrome of severe liver function impairment, which causes hepatic coma and the decrease in synthesizing capacity of liver, and develops within eight weeks of the onset of hepatitis. Several independent factors influence the survival of patients: age, the cause of liver disease, the degree and the duration of encephalopathy in relation to the onset of the disease, and the prevention of complications. Over the years many intensive treatments have been practiced. Liver transplantation is expensive, and patients who survive transplantation require life-long immunosupression, clinical care and complications management. Without transplantation fulminant hepatitis and hepatic failure might be completely recovered spontaneously, and the patient could expect a normal life. Two cases of fulminant B hepatitis with intensive care treatment, and their survival despite unfavorable prognosis are presented in this paper. The menagement of patients with fulminant hepatitis required intensive monitoring and therapeutic measures, including corticosteroids. The prognosis for survival without transplantation in fulminant hepatitis is limited by the measures of medical treatment and new specific therapeutic modalities which must be developed through basic research. Fulminantni hepatitis ili fulminantna insuficijencija jetre se definise kao klnicki sindrom izrazenog ostecenja funkcije jetre koji dovodi do kome i smanjenja sintetskog kapaciteta jetre, a razvija se u toku osam nedelja od pocetka hepatitisa. Vise nezavisnih faktora utice na prezivljavanje ukljucujuci starost bolesnika, uzrok oboljenja jetre, stepen izrazenosti i trajanje encefalopatije u odnosu na pocetak bolesti, kao i prevencija komplikacija. Tokom vremena mnogi terapijski tretmani su primenjeni u lecenju. Transplantacija je skupa, a bolesnicima koji prezive transplantaciju neophodna je dozivotna imunosupresija, klinicka nega i lecenje komplikacija. Bez transplantacije insuficijentna jetra moze biti kompletno oporavljena, a nakon spontanog oporavka moze se normalno ziveti. Prikazali smo dva slucaja fulminantnog B hepatitisa koji su, uprkos losoj prognozi, preziveli uz intenzivni tretman. Medicinski tretman bolesnika sa fulminantnim hepatitisom iziskuje intenzivni nadzor i intenzivne terapijske mere koje ukljucuju i kortikosteroide. Prognoza kod fulminantog hepatitisa gledana kroz prezivljavanje, a bez transplantacije, omedjena je merama medicinskog tertmana i novim specificnim terapijskim modalitetima koji moraju biti razvijeni kroz bazicna istrazivanja. |
| Author | Dokić, Milomir Aleksić, Rada Rajić-Dimitrijević, Radmila Popović, Svetlana Begović, Vesna Hristović, Dejan |
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| SubjectTerms | acute Acute Disease adrenal cortex hormones Adult clinical chemistry test Female glucocorticosteroids hepatic encephalopathy hepatitis B Hepatitis B - complications Hepatitis B - diagnosis Hepatitis B - therapy Humans liver failure Liver Failure - diagnosis Liver Failure - etiology Liver Failure - therapy Male Middle Aged prognosis |
| Title | Fulminant hepatitis B |
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