Effect of Consecutive Dosing of Thiamphenicol on its Own Serum Concentration and Liver Drug Metabolizing Enzyme Activities

It has been reported that many drugs stimulate their own metabolism as the result of enhancement of liver drug metabolizing enzyme activities (1,2) and that chloramphemicol (CP) inhibits liver drug metabolizing enzyme activities in rats (3, 4) and humans (5). Recently, Delia Bella et al. (6) observe...

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Published inJapanese journal of pharmacology Vol. 22; no. 3; pp. 427 - 431
Main Authors OHGOH, Toshiharu, SHIOJIRI, Hiroyuki, KANAZAWA, Tamostu, SATO, Masaru, MIYAO, Kohei
Format Journal Article
LanguageEnglish
Published 1972
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Summary:It has been reported that many drugs stimulate their own metabolism as the result of enhancement of liver drug metabolizing enzyme activities (1,2) and that chloramphemicol (CP) inhibits liver drug metabolizing enzyme activities in rats (3, 4) and humans (5). Recently, Delia Bella et al. (6) observed in rats that pretreatment with phenobarbital enhanced decreases of the drug concentration in serum and chemotherapeutic activity of CP but did not affect those of thiamphenicol (TP).
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)31678-6