Effect of Consecutive Dosing of Thiamphenicol on its Own Serum Concentration and Liver Drug Metabolizing Enzyme Activities
It has been reported that many drugs stimulate their own metabolism as the result of enhancement of liver drug metabolizing enzyme activities (1,2) and that chloramphemicol (CP) inhibits liver drug metabolizing enzyme activities in rats (3, 4) and humans (5). Recently, Delia Bella et al. (6) observe...
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Published in | Japanese journal of pharmacology Vol. 22; no. 3; pp. 427 - 431 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
1972
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Online Access | Get full text |
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Summary: | It has been reported that many drugs stimulate their own metabolism as the result of enhancement of liver drug metabolizing enzyme activities (1,2) and that chloramphemicol (CP) inhibits liver drug metabolizing enzyme activities in rats (3, 4) and humans (5).
Recently, Delia Bella et al. (6) observed in rats that pretreatment with phenobarbital enhanced decreases of the drug concentration in serum and chemotherapeutic activity of CP but did not affect those of thiamphenicol (TP). |
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ISSN: | 0021-5198 1347-3506 |
DOI: | 10.1016/S0021-5198(19)31678-6 |