A NEW METHOD FOR SYNTHESIS AND ANGIOGENIC EVALUATION OF LETEPRINIM POTASSIUM AND ITS NOVEL ANALOGS

We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which is one of the candidate substances for treating Alzheimer's disease, and subsequently synthesized 4 types of corresponding novel derivatives 2-5 that have hypoxanthine or 2-chloro-6-aminopurine as the nuc...

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Bibliographic Details
Published inHeterocycles Vol. 87; no. 11; pp. 2369 - 2384
Main Authors Sakakibara, Norikazu, Tsukamoto, Ikuko, Isono, Yohei, Takata, Maki, Konishi, Ryoji, Kato, Yoshihisa, Maruyama, Tokumi
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2013
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
9-(2,3-DIDEOXY-2-FLUORO-BETA-D-THREO-PENTOFURANOSYL)ADENINE FDDA
PURINE
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Summary:We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which is one of the candidate substances for treating Alzheimer's disease, and subsequently synthesized 4 types of corresponding novel derivatives 2-5 that have hypoxanthine or 2-chloro-6-aminopurine as the nucleobase. We then determined the angiogenic activity of these compounds by using human umbilical vein endothelial cells. Compounds 1-4 showed no angiogenic potencies judging from statistical analysis, student's t-test.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-13-12824