A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating

• Published in: Turkish journal of computer and mathematics education Vol. 12; no. 5; pp. 401 - 406
• Main Author: Jinseo Lee, Hoon Cha, Moon Sam Shin, Su-In Park, Soo Hyeon Heo
• Format: Journal Article
• Language: English
• Published: Trabzon Karadeniz Technical University Distance Education Research and Application Center 11.04.2021
• Subjects: Conjugation; Cosmetics; Moisture content; Peptides; Skin; Water loss
• ISSN: 1309-4653; 1309-4653
• DOI: 10.17762/turcomat.v12i5.974

In this study, Arg 4 (R4) was conjugated with Pal-GHK to get palmitoyl heptapeptide, Pal-GHK‐R4 and wrinkle improvement clinical trials of cosmetics containing Pal-GHK‐R4 were conducted. As a result of total 21 subjects used the test products 4 weeks use on the face area; 1) measurement results of crow’s feet after 2 and 4 weeks of test products use, analysis value of crow’s feet statistically significantly decreased after 2 and 4 weeks of test products use compared to before use of products (p<0.05); 2) measurement results of skin moisturization after 2 and 4 weeks test products use, measured value of skin moisture content statistically significantly increased after 2 and 4 weeks use compared to before use of products (p<0.05); 3) measurement results of TEWL after 2 and 4 weeks use, measured value of TEWL statistically significantly decreased after 2 and 4 weeks use compared to before use of product(p<0.05); 4) there was no skin adverse event reported after using the products during the study period. Therefore, the test products containing both wrinkle improving and skin penetrating peptides, Pal-GHK‐R4 are considered to have beneficial effects on improvement of skin wrinkle, moisturization, transepidermal water loss(TEWL) after 2 and 4 weeks use of test product.