Effect of Non-surgical Periodontal Therapy on Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Chronic Periodontitis

• Published in: Journal of young pharmacists Vol. 14; no. 2; pp. 227 - 230
• Main Authors: Malik, Nida, Kalburgi, Veena, Malik, Saba, Srivastava, Sumedha, Verma, Harshita, Rai, Kalpana Sharma
• Format: Journal Article
• Language: English
• Published: Bangalore InPharm 01.04.2022
• Subjects: Gum disease; Lymphocytes; Neutrophils
• ISSN: 0975-1483; 0975-1505
• DOI: 10.5530/jyp.2022.14.42

Introduction: Haematological investigations have for long being considered as potential diagnostic and prognostic markers in the pathogenesis of Chronic Periodontitis. An exaggerated understanding of these markers with the consideration of relatively new markers Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) obtained from the peripheral blood count may serve as a potential marker in the understanding of the correlation of Chronic Periodontitis and Systemic Inflammatory Response. These markers haven’t been extensively studied in context to Periodontitis. Materials and Methods:60 Patients were enrolled and 90 samples were collected. Group A-Experimental (30 Patients) who were assessed at baseline and Post-treatment after 4 weeks and Group B-Controls (30 Patients). GI, PI, PPD, CAL, Neutrophil Count, Lymphocyte Count and Platelet counts were obtained. NLR was calculated as the ratio to Neutrophil to Lymphocyte and PLR was calculated as the ratio of Platelet to Lymphocyte. Statistical analysis of the data was performed. Results: The results varied significantly in both the groups and in the diseased group at baseline and post-treatment. The ROC cut off values for NLR and PLR was found to be 1.5 and 92.5 respectively which may be used as prognostic values for Chronic Periodontitis. Conclusion:Both the novel markers, NLR and PLR can successfully be used in the assessment of Chronic Periodontitis with the ease of applicability and can also be used further to rule out any ongoing systemic inflammatory challenge.