Effects of Narrow-band UVB Alone and in Combination with Isotretinoin on Apoptosis and Its Clinical Implications in Early Stage Mycosis Fungoides

Background: Mycosis fungoides, one of the most common subtypes of cutaneous T-cell lymphomas, is characterized by uncontrolled T cell proliferation, apoptosis resistance, and consequent chronic cutaneous inflammation. This study aims to show the effects of narrow-band ultraviolet B (UVB) alone and n...

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Published inJournal of the Turkish Academy of Dermatology Vol. 14; no. 1; pp. 6 - 11
Main Authors Taslidere, Nazan, Canoz, Ozlem, Kesikoglu, Ayten Ferahbas
Format Journal Article
LanguageEnglish
Published Istanbul Galenos Yayinevi Tic. Ltd 01.03.2020
Galenos Publishing House
Subjects
Alcohol
Antiacne agents
Antigens
Apoptosis
B cells
Biopsy
Fungal infections
Isotretinoin
Ligands
Lymphocytes
Lymphoma
Mycoses
Mycosis fungoides
Non-Hodgkin's lymphomas
Patients
Proteins
Skin
T cells
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Summary:Background: Mycosis fungoides, one of the most common subtypes of cutaneous T-cell lymphomas, is characterized by uncontrolled T cell proliferation, apoptosis resistance, and consequent chronic cutaneous inflammation. This study aims to show the effects of narrow-band ultraviolet B (UVB) alone and narrow-band UVB + isotretinoin treatments on the expression of fas, fas ligand, Bcl-2, STAT-3 and galectin-3 proteins which are responsible for apoptosis regulation, and also assess the relationship between this regulatory functions and clinical improvement. Materials and Methods: The first group received narrow-band UVB alone and the other group received narrow-band UVB combined with 0.5 mg/kg/day oral isotretinoin. After 30 sessions of treatment, biopsies from the patient groups were examined immunohistochemically for the expression of fas, fas ligand, Bcl-2, STAT-3 and galectin-3 protein. Results: In the narrow-band UVB only group, the intensity of epidermal Bcl-2 staining was found to be increased in the post-treatment samples when compared to the pre-treatment. On the other hand, epidermal staining intensities and diffuseness for fas, fas-ligand, Bcl-2, STAT-3, and galectin-3, and also the intensities and diffuseness of epidermal lymphocyte staining and presence of epidermal cells were similar between pre and post-treatment samples within each group separately, and between the two treatment groups overall. Conclusion: In the treatment of early stage mycosis fungoides, darband UVB and retinoic acid are used. In our study, the effects of these treatments on apoptosis could not be demonstrated. Larger series studies are needed in this regard. Keywords: Mycosis fungoides, Narrow-band ultraviolet B, Isotretinoin
ISSN:1307-394X
1307-394X
DOI:10.4274/jtad.galenos.2020.36854