Cerrahpasa Experience in Topical Immunotherapy Treatment in Patients with Alopecia Areata, Totalis and Universalis

Background: Alopecia areata is a common hair problem and affects patients psychologically. Although the disease has a wide range of treatments, the responses are variable. Materials and Methods: We retrospectively analyzed the data of 213 patients who received topical immunotherapy treatment in our...

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Published inJournal of the Turkish Academy of Dermatology Vol. 14; no. 1; pp. 19 - 22
Main Authors Askin, Ozge, Gok, Ayse Mine, Serdaroglu, Server, Kara, Beril
Format Journal Article
LanguageEnglish
Published Istanbul Galenos Yayinevi Tic. Ltd 01.03.2020
Galenos Publishing House
Subjects
Age
Allergens
Alopecia
Analysis
Apoptosis
Baldness
Care and treatment
Conflicts of interest
Ethics
Hair loss
Immunotherapy
Lymphocytes
Pathogenesis
Patients
Response rates
Statistical analysis
Systematic review
Variables
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Summary:Background: Alopecia areata is a common hair problem and affects patients psychologically. Although the disease has a wide range of treatments, the responses are variable. Materials and Methods: We retrospectively analyzed the data of 213 patients who received topical immunotherapy treatment in our clinic between 2014 and 2019. Results: There was no significant difference in response rates in the two treatment types in women (p=0.120). The total response rate of the patients treated with squaric acid dibutyl ester (SADBE) was 42.9% (30/70) and the total response rate of the patients treated with diphenylcyclopropenone (DPCP) was significantly higher than 19.2% (10/52) (p=0.023). The mean age (9.73 years) of those who received full response from SADBE treatment was significantly lower than the mean age (12.65 year) of those who received full response from DPCP treatment (p=0.003). In all response cases, there was no significant difference between both treatment types and disease duration. Considering all the data, 1 month increase in the disease duration caused 1% worse response to the treatment (Wald=8.97, p=0.003). Considering all the data, 1 month increase in the treatment period caused 1.04% better response to the treatment (Wald=9.79, p=0.002). Those with a pre-treatment loss of less than 25% were found to be 7.5 times better than those with a pre-treatment loss of 100% (Wald=19.37 p<0.001). Considering all the data, the patients who received SADBE treatment received 2 times better response to treatment than those who received DPCP treatment (Wald=8.875, p=0.003). Conclusion: In conclusion, we think that topical immunotherapy is an important form of treatment in alopecia areata and more studies are needed. Keywords: Alopecia areata, Alopecia totalis, Alopecia universalis, Immunotherapy
ISSN:1307-394X
1307-394X
DOI:10.4274/jtad.galenos.2020.57442