Particle-size distribution of bitolterol mesylate solution delivered by four compressed-air nebulizer devices

The particle-size distribution of bitolterol mesylate solution delivered by four types of compressed-air nebulizers was determined. Before nebulization, bitolterol mesylate solution 0.2% w/v was diluted to 0.0833% w/v with 0.9% sodium chloride solution. The following commercially available nebulizer...

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Bibliographic Details
Published inAmerican journal of hospital pharmacy Vol. 44; no. 6; p. 1392
Main Authors Hunke, W A, Yu, A B
Format Journal Article
LanguageEnglish
Published United States 01.06.1987
Subjects
Aerosols
Bronchodilator Agents - administration & dosage
Ethanolamines - administration & dosage
Nebulizers and Vaporizers
Particle Size
Solutions
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Summary:The particle-size distribution of bitolterol mesylate solution delivered by four types of compressed-air nebulizers was determined. Before nebulization, bitolterol mesylate solution 0.2% w/v was diluted to 0.0833% w/v with 0.9% sodium chloride solution. The following commercially available nebulizers were tested: DeVilbiss Nebulizer Model 645, Hudson 1720 (Updraft) Hand Held Nebulizer, Bard Inspiron 002220 Mini-Neb Nebulizer, and Bunn Mini Mist Set model 0140-041. The particle-size distribution of nebulized solutions was determined with a cascade impactor contained in an in vitro apparatus designed to simulate use by a patient. Assays of bitolterol mesylate in the cascade impactor apparatus were done by high-performance liquid chromatography. Only slight differences were found in the particle-size distributions among the four types of nebulizers; the calculated average particle size ranged from 3.0 to 3.6 micron. All nebulizers tested showed satisfactory, comparable particle-size distributions and performance with bitolterol mesylate solution.
ISSN:0002-9289
DOI:10.1093/ajhp/44.6.1392