Synthesis and Antiarrhythmic Activity of 2-Diethylamino-2′,6′-Dimethylphenylacetamide Derivatives
Data on the syntheses and structures of a series of new derivatives of 2-diethylamino-2',6'-dimethylphenylacetamide are described. The results of an experimental study of the new compounds on various arrhythmia models in animals are presented. Several substances effectively preventing the...
Saved in:
Published in | Pharmaceutical chemistry journal Vol. 39; no. 7; pp. 350 - 353 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
01.07.2005
|
Online Access | Get full text |
Cover
Loading…
Summary: | Data on the syntheses and structures of a series of new derivatives of 2-diethylamino-2',6'-dimethylphenylacetamide are described. The results of an experimental study of the new compounds on various arrhythmia models in animals are presented. Several substances effectively preventing the onset of ventricular ischemia, reperfusive and toxic fibrillation, and ischemic arrhythmia have been selected, which are superior to the reference drug lidocaine with respect to their antiarrhythmic properties. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0091-150X 1573-9031 |
DOI: | 10.1007/s11094-005-0152-6 |