S846 Monitoring IBD by Intestinal Ultrasound Decreases Time to Treatment Change and Time to Remission in Comparison to Conventional Management

Methods: We performed a retrospective analysis of UPA-treated patients and assessed the time to treatment change (primary endpoint) and clinical remission (secondary endpoint) in pts receiving routine IUS monitoring compared with pts who did not receive this approach (conventional management). Clini...

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Published inThe American journal of gastroenterology Vol. 118; no. 10S; pp. S625 - S626
Main Authors Cleveland, Noa Krugliak, Picker, Emma A., Choi, Natalie K., Friedberg, Scott, Choi, David K., Rubin, David T.
Format Journal Article
LanguageEnglish
Published New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.10.2023
Subjects
Inflammatory bowel disease
Remission (Medicine)
Ultrasonic imaging
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Summary:Methods: We performed a retrospective analysis of UPA-treated patients and assessed the time to treatment change (primary endpoint) and clinical remission (secondary endpoint) in pts receiving routine IUS monitoring compared with pts who did not receive this approach (conventional management). Clinical remission was defined by Simple Clinical Colitis Activity Index (SCCAI) ≤2, or Harvey-Bradshaw Index (HBI) ≤4, and by IUS as bowel wall thickness (BWT) ≤3 mm in the colon or terminal ileum and no hyperemia by color Doppler signal (CDS). Demographics and Study Findings IUS (n = 11) Non-IUS Controls (n = 19) Age in years, mean (st. dev) 44.6 (12.5) 31.9 (10.6) Disease duration in years, mean (st. dev) 14 (10.1) 11.2 (8.7) Gender, % (n)  Male 55.6 (5) 72.7 (8)  Female 44.4 (4) 27.3 (3) IBD diagnosis, % (n)  Crohn's 44.4 (4) 54.5 (6)  UC 55.6 (5) 45.5 (5) Disease classification, % (n)  E1 0.0 (0) 0.0 (0)  E2 25.0 (1) 33.3 (1)  E3 76.0 (3) 66.7 (2)  L1 0.0 (0) 0.0 (0)  L2 0.0 (0) 16.7 (1)  L3 100.0 (5) 83.3 (5)  L4 0.0 (0) 0.0 (0)  B1 40.0 (2) 50.0 (3)  B2 40.0 (2) 0.0 (0)  B3 40.0 (2) 50.0 (3)  Perianal disease 20.0 (1) 16.7 (1) SCCAI, mean (st. dev) 1.8 (3.3) 3.9 (3.5) HBI, mean (st. dev) 3.5 (0.5) 8.5 (2.4) Positive clinical index, % (n) 36.4 (4) 73.7 (14) Positive FCP, % (n) 36.4 (4) 68.4 (13) Positive IUS, % (n) 100.1 (11) Active disease, % (n) 100.0 (11) 100.0 (19) Author Notes *Presenter
ISSN:0002-9270
1572-0241
DOI:10.14309/01.ajg.0000953024.22784.5a