Evaluation of the novel 5-HT6 receptor radioligand, [ 11C]GSK-215083 in human

Evaluation of the 5-HT6R expression and modulation in disease states, such as Alzheimer's or other forms of dementia could provide a valuable tool for probing the role of this target in these debilitating disease states. Regions of interest were delineated on caudate, putamen and frontal cortex...

Full description

Saved in:
Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 41; p. T20
Main Authors Parker, Christine A., Cunningham, V.J., Martarello, L., Rabiner, E.A., Searle, G.E., Gee, A.D., Davy, M., Johnson, C.N., Ahmed, M., Gunn, R.N., Laruelle, M.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 2008
Elsevier Limited
Subjects
Brain
Online AccessGet full text

Cover

More Information
Summary:Evaluation of the 5-HT6R expression and modulation in disease states, such as Alzheimer's or other forms of dementia could provide a valuable tool for probing the role of this target in these debilitating disease states. Regions of interest were delineated on caudate, putamen and frontal cortex and applied to the PET data to derive regional time activity curves.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2008.04.194