Enantioselective Synthesis of α-Alkoxy-Phosphonates by Chiral Phase Transfer Catalysis

Enantioselective PTC phosphorylation of aldehydes performed in a two phase (aq. NaOH/toluene) system mediated by chiral crown ether incorporating one or two sugar units. To avoid the rearrangement of hydroxy phosphonate 3 to nonchiral mixed phosphate ester 4 the hydroxy phosphonate was trapped by al...

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Published inPhosphorus, sulfur, and silicon and the related elements Vol. 147; no. 1; p. 135
Main Authors Jászay, Zsuzsa M., Petneházy, Imre, Szabó, Árpád, Bakó, Péter, Clementis, György, Töke, László
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.01.1999
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Summary:Enantioselective PTC phosphorylation of aldehydes performed in a two phase (aq. NaOH/toluene) system mediated by chiral crown ether incorporating one or two sugar units. To avoid the rearrangement of hydroxy phosphonate 3 to nonchiral mixed phosphate ester 4 the hydroxy phosphonate was trapped by alkylation to give 5.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426509908053548