Inosine triphosphate pyrophosphatase enhances the effect of ribavirin on hepatitis C virus cell culture infection

• Published in: Journal of hepatology Vol. 66; no. 1; p. S321
• Main Authors: Nyström, K, Pettersson, G, Wanrooij, P.H, Brunet, S, Said, J, Ortolani, G, Waldenström, J, Adamek, L, Tang, K.-W, Norberg, P, Chabes, A, Hellstrand, K, Norder, H, Lagging, M
• Format: Journal Article
• Language: English
• Published: 2017
• Subjects: Gastroenterology and Hepatology

Genetic variants of the inosine triphosphate pyrophosphatase gene (ITPA), resulting in decreased enzymatic activity of the corresponding enzyme, ITPase, are known to correlate with a decreased risk of ribavirin-induced anemia, but are also associated with an increased SVR in patients treated with pe...