Inosine triphosphate pyrophosphatase enhances the effect of ribavirin on hepatitis C virus cell culture infection

Genetic variants of the inosine triphosphate pyrophosphatase gene (ITPA), resulting in decreased enzymatic activity of the corresponding enzyme, ITPase, are known to correlate with a decreased risk of ribavirin-induced anemia, but are also associated with an increased SVR in patients treated with pe...

Full description

Saved in:
Bibliographic Details
Published inJournal of hepatology Vol. 66; no. 1; p. S321
Main Authors Nyström, K, Pettersson, G, Wanrooij, P.H, Brunet, S, Said, J, Ortolani, G, Waldenström, J, Adamek, L, Tang, K.-W, Norberg, P, Chabes, A, Hellstrand, K, Norder, H, Lagging, M
Format Journal Article
LanguageEnglish
Published 2017
Subjects
Gastroenterology and Hepatology
Online AccessGet full text

Cover

More Information
Summary:Genetic variants of the inosine triphosphate pyrophosphatase gene (ITPA), resulting in decreased enzymatic activity of the corresponding enzyme, ITPase, are known to correlate with a decreased risk of ribavirin-induced anemia, but are also associated with an increased SVR in patients treated with peginterferon-alpha and ribavirin. As both ITPase and ribavirin are involved in the nucleotide salvage pathway and reduced risk of relapse after treatment of hepatitis C, we have investigated the effect of ITPase activity and ribavirin treatment of HCVcc infection of hepatocytes
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(17)30965-0