Cerebral nicotinic acetylcholine receptors in the periventricular white matter in patients with Alzheimer's disease and vascular dementia—a 2-[18F]F-A85380 PET investigation

The mechanism of this cholinergic response in VaD remains poorly understood. Since white matter (WM) lesions play a crucial role in small vessel VaD, this PET study was initiated to investigate the state of the nAChR in WM in AD, AD with additional WM lesions and VaD using 2-[18F]F-A85380 (2-FA).

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Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 31; p. T150
Main Authors Kendziorra, Kai, Meyer, P., Wolf, H., Hesse, S., Barthel, H., Becker, G., Schildan, A., Lobsien, D., Sorger, D., Seese, A., Gertz, H.J., Sabri, O.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 2006
Elsevier Limited
Subjects
Alzheimer's disease
Dementia
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Summary:The mechanism of this cholinergic response in VaD remains poorly understood. Since white matter (WM) lesions play a crucial role in small vessel VaD, this PET study was initiated to investigate the state of the nAChR in WM in AD, AD with additional WM lesions and VaD using 2-[18F]F-A85380 (2-FA).
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.04.133