[18F]FTC-146: A novel and highly selective PET ligand for visualizing sigma-1 receptors in living subjects

Cell uptake studies showed that the level of [18F]FTC-146 accumulation correlated well (up to 4 times higher in transfected than control cells) with the levels of sigma-1 receptor expression. microPET images of [18F]FTC-146 in normal anaesthetized mice showed high uptake of the radioligand in expect...

Full description

Saved in:
Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 52; no. S1; pp. S123 - S124
Main Authors James, Michelle L., Shen, Bin, Zavaleta, Cristina, Berganos, Rhona A., Mesangeau, Christophe, Shaikh, Jamaluddin, Gambhir, Sanjiv S., Matsumoto, Rae R., McCurdy, Christopher R., Chin⁎, Frederick T.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.08.2010
Elsevier Limited
Subjects
Ligands
Medical imaging
Medical research
Rodents
Studies
Online AccessGet full text

Cover

More Information
Summary:Cell uptake studies showed that the level of [18F]FTC-146 accumulation correlated well (up to 4 times higher in transfected than control cells) with the levels of sigma-1 receptor expression. microPET images of [18F]FTC-146 in normal anaesthetized mice showed high uptake of the radioligand in expected sigma-1 rich regions (i.e., brain, heart, lung and liver) but was also seen in bone.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.04.101