Intravascular and Extravascular Microvessel Formation in Chronic Total Occlusions

• Published in: JACC. Cardiovascular imaging Vol. 3; no. 8; pp. 797 - 805
• Main Authors: Munce, Nigel R., PhD, Strauss, Bradley H., MD, PhD, Qi, Xiuling, PhD, Weisbrod, Max J, Anderson, Kevan J., BEng, Leung, General, MSc, Sparkes, John D., MSc, Lockwood, Julia, Jaffe, Ronen, MD, Butany, Jagdish, MD, Teitelbaum, Aaron A., MD, MSc, Qiang, Beiping, MD, PhD, Dick, Alexander J., MD, Wright, Graham A., PhD
• Format: Journal Article
• Language: English
• Published: 01.08.2010
• Subjects: Cardiovascular; chronic total occlusions; micro-computed tomography; IMV; μCT; intravascular microvessel volume; microchannels; chronic total occlusion; interventional cardiology; CTO
• ISSN: 1936-878X
• DOI: 10.1016/j.jcmg.2010.03.013

Intravascular and Extravascular Microvessel Formation in Chronic Total Occlusions: A Micro-CT Imaging Study Nigel R. Munce, Bradley H. Strauss, Xiuling Qi, Max J. Weisbrod, Kevan J. Anderson, General Leung, John D. Sparkes, Julia Lockwood, Ronen Jaffe, Jagdish Butany, Aaron A. Teitelbaum, Beiping Qiang, Alexander J. Dick, Graham A. Wright Micro-computed tomography (CT) imaging was used to study the formation of coronary microvessels after thrombotic coronary artery occlusion in an animal model. Micro-CT yielded very high-resolution angiographic images and demonstrated that circumferentially oriented “extravascular” microvessels developed early (peak at 2 weeks) and then receded over the following weeks. Longitudinally oriented “intravascular” microvessels formed later and peaked at 6 weeks after the occlusion. This information, bearing in mind the limitations of an animal model, may be useful for developing interventional or medical treatment of total coronary occlusions.