Immunohistochemical studies of Langerhans cells and Thy-1 positive cells in mouse tongue epithelium subjected to local hyperthermia
Hyperthermia has been used to treat cancer. However, hyperthermia has been shown to suppress skin-associated immune responses. To examine the effect of heat on immunologically responsive cells in oral mucosa, mouse tongue was heated by an implant heating system at 43°C for 20 min. The densities of L...
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| Published in | Japanese Journal of Oral and Maxillofacial Surgery Vol. 47; no. 2; pp. 83 - 88 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Society of Oral and Maxillofacial Surgeons
2001
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.47.83 |
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| Abstract | Hyperthermia has been used to treat cancer. However, hyperthermia has been shown to suppress skin-associated immune responses. To examine the effect of heat on immunologically responsive cells in oral mucosa, mouse tongue was heated by an implant heating system at 43°C for 20 min. The densities of Langerhans cells and Thy-1 positive cells in mouse lingual epithelium rapidly increased after treatment and then returned to a normal level after 7 days. Light microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphocytic cells, suggesting an active immune response to hyperthermia. |
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| AbstractList | Hyperthermia has been used to treat cancer. However, hyperthermia has been shown to suppress skin-associated immune responses. To examine the effect of heat on immunologically responsive cells in oral mucosa, mouse tongue was heated by an implant heating system at 43°C for 20 min. The densities of Langerhans cells and Thy-1 positive cells in mouse lingual epithelium rapidly increased after treatment and then returned to a normal level after 7 days. Light microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphocytic cells, suggesting an active immune response to hyperthermia. |
| Author | UEDA, Minoru KOBAYASHI, Miya TOHNAI, Iwai HAYASHI, Yasushi MITSUDO, Kenji |
| Author_xml | – sequence: 1 fullname: TOHNAI, Iwai organization: Department of Maxillofacial Surgery, Postgraduate School of Medicine, Nagoya University – sequence: 1 fullname: MITSUDO, Kenji organization: Department of Maxillofacial Surgery, Postgraduate School of Medicine, Nagoya University – sequence: 1 fullname: KOBAYASHI, Miya organization: Department of Anatomy, Nagoya University School of Medicine – sequence: 1 fullname: UEDA, Minoru organization: Department of Maxillofacial Surgery, Postgraduate School of Medicine, Nagoya University – sequence: 1 fullname: HAYASHI, Yasushi organization: Department of Maxillofacial Surgery, Postgraduate School of Medicine, Nagoya University |
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| References | 15) Lombardi, T., Hauser, C., et al.: Langerhans cells: structure, function and role in oral pathological conditions. J Oral Pathol Med 22: 193-202 1993. 2) Yoshioka, A., Miyachi, Y., et al.: Suppression of contact sensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice. Br J Dermatol 120: 493-501 1989. 11) Niwa, J., Kobayashi M., et al.: Langerhans cells closely associated with Thy-1-positive dendritic cells in the stratified squamous mucosal epithelium of mice. Arch Histol Cytol 57: 259-266 1994. 16) Matsui, M., Shimizu, T., et al.: Research on hyperthermic implant materials from a point of view of material science. In hyperthermic Oncology '86 in Japan, MAG BROS Inc, Tokyo 63-64 1987. 10) Kotani, H., Kobayashi, M., et al.: Langerhans cells in the developing mucosal epithelium of mice. Arch Histol Cytol 54: 51-58 1991. 14) 佐藤方信, 大津匡志, 他: ヒト舌癌におけるLangerhans細胞の検討. 口科誌41: 66-70 1992. 7) 後藤康之, 藤内祝, 他; Implant Heating Systemによる口腔悪性腫瘍に対する組織内温熱療法-家兎腫瘍モデルによる検討-口本ハイパーサーミア誌6: 439-449 1990. 5) Baxter, C. S., Andringa, A., et al.: Effect of tumor-promoting agents on density and morphometric parameters of mouse epidermal Langerhans and Thy-1+ cells. Carcinogenesis 12: 1017-1021 1991. 13) 金本恵子: 口腔扁平上皮癌におけるランゲルハンス細胞の検索. 口口外誌37: 1623-1632 1991. 6) Kobayashi, T., Tanaka, T., et al.: Interstitial hyperthermia of experimental brain tumor using implant heating system. J Neuro-Oncol 7: 201-208 1989. 4) Choi, K. L. and Sauder, D. N.: The role of Langerhans cells and keratinocytes in epidermal immunity. J Leuk Biol 39: 343-358 1986. 12) Walsh, L. J., Savage, N. W., et al.: Immunopathogenesis of oral lichen planus. J Oral Pathol Med 19: 389-396 1990. 17) Tohnai, I., Hayashi, Y., et al.: Thermochemotherapy of using magnetic induction hyperthermia (Implant Heating System: IHS) for cancer of the tongue. Nagoya J Med Sci 59: 49-54 1996. 8) Robins, P. G. and Bandon, D. R.: A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells. Stain Technol 56: 87-89 1981. 1) Abe, M. and Hiraoka, M.: Localized hyperthermia and radiation in cancer therapy. Int J Radiat Biol 47: 347-359 1985. 9) Cruchley, A. T., William, D. M., et al.: Regional variation in Langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against CD 1, HLA-DR, HLA-DQ, and HLA-DP. J Oral Pathol Med 18: 510-516 1989. 3) Young, J. O., Jong, Y. Y., et al.: Hyperthermia depletes epidermal Langerhans cells and modulates contact hypersensitivity reaction in mice. Annals Dermatol 2: 71-76 1990. |
| References_xml | – reference: 6) Kobayashi, T., Tanaka, T., et al.: Interstitial hyperthermia of experimental brain tumor using implant heating system. J Neuro-Oncol 7: 201-208 1989. – reference: 11) Niwa, J., Kobayashi M., et al.: Langerhans cells closely associated with Thy-1-positive dendritic cells in the stratified squamous mucosal epithelium of mice. Arch Histol Cytol 57: 259-266 1994. – reference: 14) 佐藤方信, 大津匡志, 他: ヒト舌癌におけるLangerhans細胞の検討. 口科誌41: 66-70 1992. – reference: 3) Young, J. O., Jong, Y. Y., et al.: Hyperthermia depletes epidermal Langerhans cells and modulates contact hypersensitivity reaction in mice. Annals Dermatol 2: 71-76 1990. – reference: 13) 金本恵子: 口腔扁平上皮癌におけるランゲルハンス細胞の検索. 口口外誌37: 1623-1632 1991. – reference: 9) Cruchley, A. T., William, D. M., et al.: Regional variation in Langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against CD 1, HLA-DR, HLA-DQ, and HLA-DP. J Oral Pathol Med 18: 510-516 1989. – reference: 10) Kotani, H., Kobayashi, M., et al.: Langerhans cells in the developing mucosal epithelium of mice. Arch Histol Cytol 54: 51-58 1991. – reference: 8) Robins, P. G. and Bandon, D. R.: A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells. Stain Technol 56: 87-89 1981. – reference: 7) 後藤康之, 藤内祝, 他; Implant Heating Systemによる口腔悪性腫瘍に対する組織内温熱療法-家兎腫瘍モデルによる検討-口本ハイパーサーミア誌6: 439-449 1990. – reference: 17) Tohnai, I., Hayashi, Y., et al.: Thermochemotherapy of using magnetic induction hyperthermia (Implant Heating System: IHS) for cancer of the tongue. Nagoya J Med Sci 59: 49-54 1996. – reference: 15) Lombardi, T., Hauser, C., et al.: Langerhans cells: structure, function and role in oral pathological conditions. J Oral Pathol Med 22: 193-202 1993. – reference: 2) Yoshioka, A., Miyachi, Y., et al.: Suppression of contact sensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice. Br J Dermatol 120: 493-501 1989. – reference: 1) Abe, M. and Hiraoka, M.: Localized hyperthermia and radiation in cancer therapy. Int J Radiat Biol 47: 347-359 1985. – reference: 16) Matsui, M., Shimizu, T., et al.: Research on hyperthermic implant materials from a point of view of material science. In hyperthermic Oncology '86 in Japan, MAG BROS Inc, Tokyo 63-64 1987. – reference: 4) Choi, K. L. and Sauder, D. N.: The role of Langerhans cells and keratinocytes in epidermal immunity. J Leuk Biol 39: 343-358 1986. – reference: 5) Baxter, C. S., Andringa, A., et al.: Effect of tumor-promoting agents on density and morphometric parameters of mouse epidermal Langerhans and Thy-1+ cells. Carcinogenesis 12: 1017-1021 1991. – reference: 12) Walsh, L. J., Savage, N. W., et al.: Immunopathogenesis of oral lichen planus. J Oral Pathol Med 19: 389-396 1990. |
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| SubjectTerms | hyperthermia immunohistochemistry Langerhans cell Thy-1 positive cell tongue mucosa |
| Title | Immunohistochemical studies of Langerhans cells and Thy-1 positive cells in mouse tongue epithelium subjected to local hyperthermia |
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