Immunohistochemical studies of Langerhans cells and Thy-1 positive cells in mouse tongue epithelium subjected to local hyperthermia

Hyperthermia has been used to treat cancer. However, hyperthermia has been shown to suppress skin-associated immune responses. To examine the effect of heat on immunologically responsive cells in oral mucosa, mouse tongue was heated by an implant heating system at 43°C for 20 min. The densities of L...

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Bibliographic Details
Published inJapanese Journal of Oral and Maxillofacial Surgery Vol. 47; no. 2; pp. 83 - 88
Main Authors TOHNAI, Iwai, MITSUDO, Kenji, KOBAYASHI, Miya, UEDA, Minoru, HAYASHI, Yasushi
Format Journal Article
LanguageEnglish
Published Japanese Society of Oral and Maxillofacial Surgeons 2001
Subjects
hyperthermia
immunohistochemistry
Langerhans cell
Thy-1 positive cell
tongue mucosa
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ISSN0021-5163
2186-1579
DOI10.5794/jjoms.47.83

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Summary:Hyperthermia has been used to treat cancer. However, hyperthermia has been shown to suppress skin-associated immune responses. To examine the effect of heat on immunologically responsive cells in oral mucosa, mouse tongue was heated by an implant heating system at 43°C for 20 min. The densities of Langerhans cells and Thy-1 positive cells in mouse lingual epithelium rapidly increased after treatment and then returned to a normal level after 7 days. Light microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphocytic cells, suggesting an active immune response to hyperthermia.
ISSN:0021-5163
2186-1579
DOI:10.5794/jjoms.47.83