Fascinating Dendritic Cells—Sentinel Cells of the Immune System a Review

Dendritic cells (DC) are specialized antigen presenting cells which have the unique ability to activate naive T-lymphocytes. Their role in the immune system is much more sophisticated than it seems, as they do not kill the pathogens directly, but provide a long-lasting antigen specific immune respon...

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Bibliographic Details
Published inFolia Veterinaria Vol. 65; no. 4; pp. 12 - 19
Main Authors Kiššová Z., Tkáčiková Ľ.
Format Journal Article
LanguageEnglish
Published Sciendo 01.12.2021
Subjects
anti-tumour immunity
dendritic cells
immune response
t-lymphocytes
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Summary:Dendritic cells (DC) are specialized antigen presenting cells which have the unique ability to activate naive T-lymphocytes. Their role in the immune system is much more sophisticated than it seems, as they do not kill the pathogens directly, but provide a long-lasting antigen specific immune response thanks to that sufficiently bridging the innate and the adaptive immunity. In recent years, there has been a growing interest in studies of their role in immune regulation, autoimmune reactions, as well as in immune responses against pathogens and tumours. Processing and presentation capabilities of a highly specific and unique tumour antigen makes them an interesting tool for stimulating effective anti-tumour immunity. In vitro generations of DC represent a preferred model for more detailed studies of DC biology in other fields. The aim of this review was to discuss the main role of dendritic cells in the body as well as their current use as experimental models for further scientific studies.
ISSN:2453-7837
DOI:10.2478/fv-2021-0033