Relationship between Propofol Concentration of Jugular Venous Bulb Blood and Jugular Venous Bulb Blood Oxygen Saturation or Somatosensory Evoked Potential in Carotid Endarterectomy Patients

• Published in: Nihon Rinshō Masui Gakkai shi Vol. 20; no. 2; pp. 91 - 96
• Main Authors: UESUGI, Fumihiko, SAKAI, Akihiko, NAKAGAWA, Itsuo, HAMADA, Hiroshi, KIMURA, Miyou
• Format: Journal Article
• Language: English
• Published: THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA 2000
• Subjects: Cerebral blood flow; Concentrations of jugular venous bulb blood; Propofol
• ISSN: 0285-4945; 1349-9149
• DOI: 10.2199/jjsca.20.91

The time course of propofol concentrations of the arterial and jugular venous bulb blood, and their effects on the change of jugular venous bulb blood oxygen saturation (SjO2) and somatosensory evoked potential (SEP) were examined in carotid endarterectomy (CEA) patients. Twelve patients were deviled into two groups; group I (n=6) received propofol infusion at a rate of 10mg•kg-1•h-1, and infusion rate were gradually reduced to 8, 6, 4mg•kg-1•h-1 with 10 minutes durations. Group II (n=6) received continuous propofol infusion at a rate of 5mg•kg-1•h-1 with 40 minutes durations. The value of SjO2 and the amplitude of SEP were significantly decreased following the infusion of propofol in two groups. In group I, propofol concentrations of arterial blood did not correlate with SjO2 and SEP, however propofol concentrations of jugular venous bulb blood correlated with SjO2. In group II, there existed correlation between jugular venous concentrations and SjO2 or SEP. It is concluded that an arterial blood propofol concentration alone may fail to predict the effects of propofol on cerebral blood flow or cerebral metabolism, and the propofol concentrations of jugular venous bulb blood are useful for concidering the cerebral effects of propofol.