The Biological Properties of Lactoferrin

Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions from exocrine glands and the content of specific granules of neutrophils. It has been reported to have numerous functions. Due to antimicrobial and anti-inf...

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Bibliographic Details
Published inCentral European Journal of Sport Sciences and Medicine Vol. 15; pp. 15 - 25
Main Authors Trybek, Grzegorz, Metlerski, Marcin, Szumilas, Kamila, Aniko-Włodarczyk, Magda, Preuss, Olga, Grocholewicz, Katarzyna, Wiszniewska, Barbara
Format Journal Article
LanguageEnglish
Published Wydawnictwo Naukowe Uniwersytetu Szczecińskiego 2016
Subjects
antimicrobial activity
immunomodulatory effect
lactoferrin
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Summary:Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions from exocrine glands and the content of specific granules of neutrophils. It has been reported to have numerous functions. Due to antimicrobial and anti-inflammatory activity, the lactoferrin plays significant role in host defense against infection and extreme inflammation. Recent studies have also demonstrated that LF can protect against cancer in experimental animals and has anticarcinogenic activity in many human tumors. At the cellular level, LF modulates the proliferation, differentiation, maturation, activation, migration and function of immune cells. This review presents the multifunctional roles and specific beneficial properties of lactoferrin.
ISSN:2300-9705
2353-2807
DOI:10.18276/cej.2016.3-02