Radiolabeling, biological distribution, docking and ADME studies of 99mTc-Ros as a promising natural tumor tracer

Rosmarinic acid (Ros) is one of phenolic metabolites with powerful potency as an anticancer agent, with different mechanisms to diminish the cancer cells. This current study represents radiolabeling of Ros with 99mTc using SnCl2 in pH4 for 15 min at 60 °C, The yield up to 92.2%. Biological evaluatio...

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Bibliographic Details
Published inApplied radiation and isotopes Vol. 184; p. 110196
Main Authors El-Sharawy, Dina M., Khater, S.I., El Refaye, Marwa S., Hassan, Hossam M., AboulMagd, Asmaa M., Aboseada, Mahmmoud A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2022
Subjects
ADME
Molecular docking
Radiolabeling
Rosmarinic acid
Radiolabeling
Rosmarinic acid
ADME
Molecular docking
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Summary:Rosmarinic acid (Ros) is one of phenolic metabolites with powerful potency as an anticancer agent, with different mechanisms to diminish the cancer cells. This current study represents radiolabeling of Ros with 99mTc using SnCl2 in pH4 for 15 min at 60 °C, The yield up to 92.2%. Biological evaluation in normal and cancer mice revealed the localization of the tracer in tumor tissue. Furthermore, docking and ADME (Absorption, Distribution, Metabolism, and Excretion) studies were performed, The resulted data clarifies the use of Ros as a promissing natural tracer. •Radiolabeling of rosmarenic acid.•Rosmarinic acid have a promising effect as anticancer agent.•Using 99mTc in labeling process.•Make a useful natural tracer for tumor targeting.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2022.110196