Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinoline N-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This re...

Full description

Saved in:
Bibliographic Details
Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 23; no. 14; pp. 5049 - 5055
Main Authors Mandal, Susanta, Bhuyan, Samuzal, Jana, Saibal, Hossain, Jagir, Chhetri, Karan, Roy, Biswajit Gopal
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.07.2021
Royal Society of Chemistry
Subjects
Catalysts
Chemistry
Chemistry, Multidisciplinary
Green & Sustainable Science & Technology
Green chemistry
N-Oxides
Natural products
NMR
Nuclear magnetic resonance
Oxides
Photocatalysis
Physical Sciences
Quinoline
Reagents
Science & Technology
Science & Technology - Other Topics
Synthesis
DESIGN
1-OXIDES
IN-VIVO
INHIBITORY-ACTIVITY
GLYCINE SITE
ANTAGONISTS
PHOTOLYSIS
FACILE
DERIVATIVES
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.
ISSN:1463-9262
1463-9270
DOI:10.1039/d1gc01460a