Recent progress in antisolvent crystallization

• Published in: CrystEngComm Vol. 24; no. 17; pp. 3122 - 3135
• Main Authors: Jia, Shengzhe, Yang, Peng, Gao, Zhenguo, Li, Zhonghua, Fang, Chen, Gong, Junbo
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 03.05.2022
• Subjects: Crystallization; Design optimization; Optimization; Parameter modification; Pharmaceutical industry; Pharmaceuticals; Polymorphism; Process intensification; Process parameters
• ISSN: 1466-8033; 1466-8033
• DOI: 10.1039/D2CE00059H

Antisolvent crystallization is a significant unit operation in the pharmaceutical industry, especially in drug crystal property optimization. This paper firstly highlights the applications of antisolvent crystallization in crystal engineering. Antisolvent crystallization can effectively control the product properties, such as polymorphism, morphology, and particle size optimization, to improve drug therapeutic effect. This paper also includes the process intensification pathways of antisolvent crystallization in the pharmaceutical field. Process parameter optimization and device and structure modification are considered as feasible approaches. Then, coupled techniques with antisolvent crystallization, including ultrasound and membrane intensification, are also summarized. Finally, the models and applications of continuous antisolvent crystallization are introduced to better design and optimize the processes. Also, critical concerns and opportunities for further research and perspectives are discussed.