Association of vitamin D 3 with alveolar bone regeneration in dogs

Abstract Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D 3 and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non‐Vit.D...

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Published inJournal of cellular and molecular medicine Vol. 19; no. 6; pp. 1208 - 1217
Main Authors Hong, Hsiang‐Hsi, Yen, Tzung‐Hai, Hong, Adrienne, Chou, Ting‐An
Format Journal Article
LanguageEnglish
Published Chichester John Wiley & Sons, Inc 01.06.2015
Subjects
Alveolar bone
Bone density
Bone growth
Bone resorption
Calcitriol
Calcium
Calcium phosphates
Defects
Dogs
Fractures
Growth factors
Laboratories
Mandible
Metabolites
Mineralization
Osteogenesis
Phosphorus
Regeneration
Skin & tissue grafts
Studies
Vitamin D
Vitamin D3
Taiwan
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Summary:Abstract Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D 3 and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non‐Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption ( VRR ), bone density (density), new bone formation ( NBF ) and implant stability quotient ( ISQ ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF /Density/ VRR and the Alloplast subgroup on items NBF /Density/ ISQ / VRR . Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF /Density/ ISQ ( P  < 0.001) and a lower VRR value ( P  = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF ( P  = 0.349), density ( P  = 0.796), ISQ ( P  = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non‐Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF /Density/ ISQ ( P  = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D 3 treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D 3 treatment displayed a superior stimulating effect than local vitamin D 3 application did.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.12460