Pharmacology and Therapeutic Potential of the 5-HT 7 Receptor

• Published in: ACS chemical neuroscience Vol. 10; no. 1; pp. 89 - 119
• Main Authors: Blattner, Kevin M., Canney, Daniel J., Pippin, Douglas A., Blass, Benjamin E.
• Format: Journal Article
• Language: English
• Published: United States 16.01.2019
• Subjects: Animals; Drug Discovery - trends; Humans; Neoplasms - drug therapy; Neoplasms - metabolism; Nervous System Diseases - drug therapy; Nervous System Diseases - metabolism; Protein Multimerization - drug effects; Protein Multimerization - physiology; Protein Structure, Secondary; Receptors, Serotonin - chemistry; Receptors, Serotonin - metabolism; Serotonin - chemistry; Serotonin - metabolism; Serotonin Antagonists - chemistry; Serotonin Antagonists - metabolism; Serotonin Antagonists - therapeutic use; Serotonin Receptor Agonists - chemistry; Serotonin Receptor Agonists - metabolism; Serotonin Receptor Agonists - therapeutic use; 5-HT7 receptor; serotonin (5-HT); G-protein-coupled receptor (GPCR); 5-HT7 antagonist; 5-HT7 agonist; Serotonin receptor
• ISSN: 1948-7193; 1948-7193
• DOI: 10.1021/acschemneuro.8b00283

It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT , was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT in normal physiology and the therapeutic potential of this interesting drug target.