Terlipressin versus adrenaline in refractory septic shock
Objective The aim of this study was to compare terlipressin versus adrenaline in refractory septic shock. Patients and methods In this interventional prospective randomized study, 80 patients between 18 and 60 years of age who presented with refractory septic shock were enrolled. The patients were d...
Saved in:
Published in | Ain-Shams Journal of Anaesthesiology Vol. 9; no. 2; pp. 186 - 193 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Ain Shams University, Faculty of Medicine, Department of Anesthesiology
01.04.2016
Wolters Kluwer - Medknow Publications Medknow Publications and Media Pvt. Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Objective
The aim of this study was to compare terlipressin versus adrenaline in refractory septic shock.
Patients and methods
In this interventional prospective randomized study, 80 patients between 18 and 60 years
of age who presented with refractory septic shock were enrolled. The patients were divided
randomly into two groups of 40 patients each. Group A patients were treated with adrenaline
and group T patients were treated with terlipressin. The goals of the therapy were to achieve and
maintain for 6 h all of the following: (i) mean blood pressure greater than 65 mmHg; (ii) systemic
vascular resistance index greater than 1300 dynes s/cm5/m2; (iii) cardiac index (CI) greater
than 4.0 l/min/m2; and (iv) oxygen delivery index greater than 550 ml/min/m2. The patients
were classifi ed into responders and nonresponders to the drugs used.
Results
The number of responders was signifi cantly higher in the terlipressin group. There were
23 (58.97%) responders in the T group and 13 (35.13%) responders in the A group. The
terlipressin group showed a signifi cant increase in mean blood pressure from 49.9 ± 14.82
to 77.79 ± 20 mmHg and a signifi cant increase in systemic vascular resistance index from
898 ± 292 to 1420 ± 537 dynes s/cm5/m2; urine output and creatinine clearance also showed
an increase. Group T patients showed a signifi cant decrease in heart rate and norepinephrine
infusion. As regards cardiac index and oxygen delivery index, they showed minimal decrease
at the end of the study, but their levels were still above our target levels.
Conclusion
Terlipressin therapy is better than adrenaline in improving the hemodynamic variables and
kidney functions in refractory septic-shock patients |
---|---|
ISSN: | 1687-7934 2090-925X |
DOI: | 10.4103/1687-7934.182224 |