Impact of the CYP3A4 metabolic activity and CYP2C19 Polymorphisms on Antiplatelet effects of clopidogrel in Russian Patients with acute Coronary Syndrome undergoing coronary stent implantation

Material and Methods We determined the CYP2C19 genotypes (Real-time PCR) and CYP3A4 metabolic activity (6b-hydroxycortisol/cortisol (6-OHC/FC) in urine were determined by high-performance liquid chromatography) of 81 subjects with acute coronary syndromes (ACS) undergoing coronary stent implantation...

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Published inClinical therapeutics Vol. 37; no. 8; pp. e78 - e79
Main Authors Mirzaev, K.B, Sychev, D.A, Andreev, D.A, Kazakov, R.E, Smirnov, V.V
Format Journal Article
LanguageEnglish
Published Bridgewater Elsevier Inc 01.08.2015
Elsevier Limited
Subjects
Acute coronary syndromes
Angina pectoris
Internal Medicine
Medical Education
Metabolism
Metabolites
Stents
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Summary:Material and Methods We determined the CYP2C19 genotypes (Real-time PCR) and CYP3A4 metabolic activity (6b-hydroxycortisol/cortisol (6-OHC/FC) in urine were determined by high-performance liquid chromatography) of 81 subjects with acute coronary syndromes (ACS) undergoing coronary stent implantation (62 male patients, mean age 64 years) receiving clopidogrel and evaluated the effect of these factors on on-treatment platelet aggregation using the VerifyNow P2Y12 assay.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2015.05.226