Usefulness of 18F-α-Methyltyrosine PET for Therapeutic Monitoring of Patients with Advanced Lung Cancer
L-[3- F]-α-methyl tyrosine ( F-FAMT) positron emission tomography (PET) has a high specificity for detecting malignant lesions. However, the usefulness of therapeutic monitoring of F-FAMT PET against advanced human neoplasms remains unclear. Here, we evaluated F-FAMT PET clinical significance regard...
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Published in | Anticancer research Vol. 36; no. 12; pp. 6481 - 6490 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
01.12.2016
|
Subjects | |
Online Access | Get full text |
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Summary: | L-[3-
F]-α-methyl tyrosine (
F-FAMT) positron emission tomography (PET) has a high specificity for detecting malignant lesions. However, the usefulness of therapeutic monitoring of
F-FAMT PET against advanced human neoplasms remains unclear. Here, we evaluated
F-FAMT PET clinical significance regarding therapy response and outcome after systemic chemotherapy in patients with advanced lung cancer, compared to
F-FDG PET.
All patients with untreated advanced lung cancer received
F-FAMT PET and
F-FDG PET before and 4 weeks after one cycle of chemotherapy. Metabolic response (MR) was defined according to the PERCIST guideline.
Ninety-five patients were eligible for analysis on both PET scans. The histological type included 87 non-small cell lung cancers and 8 small-cell lung cancers. Post-treatment maximal standardized uptake values (SUV
) and MR on
F-FAMT PET were correlated with tumor response. In all patients, post-treatment SUV
of
F-FDG and
F-FAMT PET and MR of
F-FAMT PET were statistically significant prognostic markers for predicting poor outcome by univariate analysis. Multivariate analysis confirmed that MR on
F-FAMT PET was a significant independent prognostic factor.
MR on
F-FAMT PET may be a potential parameter to predict the prognosis after first-line chemotherapy in patients with advanced lung cancer. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0250-7005 1791-7530 |
DOI: | 10.21873/anticanres.11247 |