Small molecules and human cardiomyogenesis: Is there a bottleneck in current research?

Human pluripotent stem cell derived cardiomyocytes (hPSCderived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSCderived CMs have been developed. Most of them utilize the modulation of human cardiomyog...

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Bibliographic Details
Published inBiodiscovery Vol. 15; no. 15; pp. 2 - 6
Main Author Trifonov, Dimitar
Format Journal Article
LanguageEnglish
Published Sofia Pensoft Publishers 31.03.2015
Subjects
Cardiomyocytes
Drug discovery
Pluripotency
Regenerative medicine
Stem cells
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Summary:Human pluripotent stem cell derived cardiomyocytes (hPSCderived CMs) have a vast potential in drug discovery, disease modeling and regenerative medicine. In recent years various differentiation protocols for hPSCderived CMs have been developed. Most of them utilize the modulation of human cardiomyogenesis via smallmolecule compounds. However, setbacks to the largescale application of hPSCderived CMs still abound: insufficient insight into important signaling pathways for cardiac lineagespecific differentiation and identification of suitable smallmolecule modulators; inconsistent results due to unstandardised culturing techniques; lack of effective maturation of hPSCderived CMs in vitro. So is there a bottleneck in current research? This paper attempts to answer this question.
ISSN:2050-2966
2050-2966
DOI:10.7750/BioDiscovery.2015.15.2