SURVIVAL AND IMMUNOEXPRESSION OF CD30 OF EXTRANODAL NATURAL KILLER/T-CELL LYMPHOMA, NASAL TYPE: AN ONCOLOGICAL CENTRE EXPERIENCE IN MÉXICO

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 128; no. 1; p. e61
• Main Authors: Avila-HernÁndez, Ms. Alma, Meneses-GarcÍa, Dr. Abelardo, Portilla-Robertson, Dr. Javier
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.07.2019
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.02.142

Extranodal Natural Killer/T-cell Lymphoma, nasal type (ENKTCL-NT) is an aggressive non-Hodgkin lymphom with poor prognosis, is predominant in Latin-America and Asia, whose validated prognostic model have not yet defined, and the prognostic value of CD30 in this disease remains controversial. The purpose of this study was to describe clinical, pathological and sociodemographic features and evaluate the survival and prognostic implications of CD30 expression of patients treated at National Cancer Institute, México. The medical records and slides histological were reviewed of ENKTCL-NT patients seen between 1999 and 2013; we used immunohistochemical method to investigate the expression of CD30. The survival curves was performed by the Kaplan-Meier method, the difference was computed by the log-rank test, and was used a multivariate Cox regression model. A total 66 patients were seen, 32 met the selection criteria. The media age was 43 years (20–81 years), the male to female ratio was 3.6:1. The 5-year Overall Survival (OS) rate was 15% (95% CI, 0.05-0.30), with nine patients (28.1%) died during follow-up of 14 years. CD30 positive expression was detected in 71.9% cases. Univariate analysis showed statistical significance (p<0.05) for immunoexpression of CD30 with Granzyma B, cellular size and sex, it was also statistically significant the time survival with immunoexpression of Granzyme B, sex and status. Multivariate analysis showed CD30 expression was not a prognostic factor for OS (p=0.492) and patients without tumor have 81% lower probability of death (RM=0.190, 95% CI, 0.0415-0.875). Data on epidemiology was similar to that seen in other Asia countries, and CD30 was not a prognostic factor for OS but was frequently expressed in ENKTCL-NT. We suggest new reports with bigger samples.