Does Blood Type Have an Effect on Response to Hepatitis B Vaccine in Children? Single Center Data

• Published in: Çocuk enfeksiyon dergisi Vol. 18; no. 2; pp. 82 - 87
• Main Authors: Uygun, Hatice, Coşkun, Mehmet Enes
• Format: Journal Article
• Language: English
• Published: Istanbul Aves Yayincilik Ltd. STI 01.06.2024
• Subjects: Age; Antibodies; Antigens; Blood groups; Chronic illnesses; Hepatitis B; Immune system; Infections; Patients; Pediatrics; Statistical analysis; Tropical diseases; Vaccines
• ISSN: 1307-1068; 1308-5271
• DOI: 10.5578/ced.20240203

Levels of isoantibodies vary significantly between individuals and determine an individual's general predisposition to form antibodies against antigens. [...]it is an indicator of the individual's functional immunological capacity and can be used to predict immune response to the vaccine (8,9). Materials and Methods Study population A total of 2.138 pediatric patients aged 1-18 years, who applied to the pediatric outpatient clinic of Gaziantep University Hospital between January 2016 and June 2018, for any reason, were included in this study. Failure to obtain anti-HBs antibody result, positive anti-HBs test result, hepatitis B surface antigen (HBsAg) positive, failure to receive three doses of hepatitis B recombinant vaccine within the first year of life, smoking, use of immunosuppressive drugs, use of corticosteroids, and having any chronic disease (e.g. obesity, protein energy deficiency, malignancy, autoimmune disease, rheumatological disease, immune system disorder, chronic hepatitis B). In the third stage, among the children selected in the first two stages, those whose blood group information could be accessed from the hospital records were recorded.