Is There a Reliable Marker (Correlate of Immune Protection) for Disease Prevention? Laboratory-Clinical Evaluation

[...]because they are expensive, time-consuming, and require specialized techniques, they are not used to determine CoP in routine clinical practice. b) CoP is defined as non-mechanistic CoP (nCoP), if CoP is achieved by a standard method that can indirectly demonstrate protection (e.g. a method tha...

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Bibliographic Details
Published inÇocuk enfeksiyon dergisi Vol. 18; no. 3; pp. 192 - 195
Main Authors Ergün Özdel, Zeynep Gizem, Hacımustafaoğlu, Mustafa Kemal
Format Journal Article
LanguageEnglish
Published Istanbul Aves Yayincilik Ltd. STI 01.09.2024
Subjects
Antibodies
Bacterial infections
Chicken pox
Disease
Hepatitis
Human papillomavirus
Immune system
Immunity (Disease)
Infections
Influenza
Laboratories
Measles
Methods
Mumps
Rubella
Serology
Vaccines
Viral infections
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Summary:[...]because they are expensive, time-consuming, and require specialized techniques, they are not used to determine CoP in routine clinical practice. b) CoP is defined as non-mechanistic CoP (nCoP), if CoP is achieved by a standard method that can indirectly demonstrate protection (e.g. a method that shows total antibodies assayed such as ELISA). In case of changes in specific epitopes in variant viruses that develop after mutation, the protective effect of neutralizing antibodies may decrease or disappear (1). [...]it is not always possible to measure this response with routine methods in practice. [...]serologic CoP values for mumps are not clear. [...]mumps cases may be observed in young adults despite vaccination (5,10-12).
ISSN:1307-1068
1308-5271
DOI:10.5578/ced.20240308