Clinicopathological Features of Five-year Survivors with T4 Esophageal Carcinoma Contribution of Preoperative Hyperthermo-chemo-radiotherapy

• Published in: Nihon Haipāsāmia Gakkai shi Vol. 17; no. 2; pp. 77 - 84
• Main Authors: NOZOE, TADAHIRO, ITOH, SHUHEI, FUTATSUGI, MOTONORI, KIMURA, YASUE, ISHIDA, MAYUMI, SAEKI, HIROSHI, OHGA, TAKEFUMI, KITAMURA, KAORU, SUGIMACHI, KEIZO
• Format: Journal Article
• Language: English
• Published: Japanese Society for Thermal Medicine 01.06.2001
• Subjects: hyperthermo-chemo-radiotherapy; prognosis; T4 esophageal carcinoma
• ISSN: 0911-2529; 1881-9516
• DOI: 10.3191/thermalmedicine.17.77

Although prognosis of patients with esophageal carcinoma, especially invading to the neighboring structures (T4), is quite unfavorable, there are occasionally patients surviving long term without recurrence of the tumor. The aim of the current study was to elucidate the clinicopathological characteristics of patients who survived over 5 years after surgical treatment for T4 esophageal carcinoma. One hundred and thirty-two patients with T4 esophageal carcinoma were studied, including 11 surviving over 5 years. The clinicopathological factors were compared between 5 years survivors and patients who died of carcinoma within 5 years after operation. A significant difference was observed between 5 years survivors and patients who died of carcinoma within 5 years after operation regarding mean age (56.9 ± 9.4 versus 62.8± 8.9 ; p=0.0375), the proportion of lymphatic invasion (0% versus 52.9% ; p=0.0008) and the proportion of marked effectiveness after preoperative therapy (30% versus 6.9% ; p=0.0341). All of the 3 patients among 5 years survivors having marked effectiveness were treated with preoperative hyperthermo-chemo-radiotherapy (HCR). HCR attributes to acquire marked effect resulting in a more favorable prognosis of patients with T4 esophageal carcinoma.