Immunohistochemical studies of proliferating cell nuclear antigen in oral squamous cell carcinoma
We immunohistochemically studied proliferating cell nuclear antigen (PCNA) in 25 oral squamous cell carcinomas. PCNA-positive cells were detected in all formalin fixed, paraffin embedded specimens. The results were as follows: 1. The PCNA-positive rate in the group with cervical lymph node metastasi...
Saved in:
| Published in | Japanese Journal of Oral and Maxillofacial Surgery Vol. 41; no. 1; pp. 1 - 5 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japanese Society of Oral and Maxillofacial Surgeons
1995
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5163 2186-1579 |
| DOI | 10.5794/jjoms.41.1 |
Cover
| Abstract | We immunohistochemically studied proliferating cell nuclear antigen (PCNA) in 25 oral squamous cell carcinomas. PCNA-positive cells were detected in all formalin fixed, paraffin embedded specimens. The results were as follows: 1. The PCNA-positive rate in the group with cervical lymph node metastasis was significantly higher than in the group with no metastasis (p<0.05). 2. The PCNA-positive rate in the group with a clinical responce of no change was significantly higher than in the group with a partial response (p<0.01). 3. The PCNA-positive rate in specimens obtained during operation was significantly lower than those obtained by biopsy (p<0.05). These results suggests that the PCNA-positive rate may be a useful factor in selecting the most effective type of antitumor therapy. |
|---|---|
| AbstractList | We immunohistochemically studied proliferating cell nuclear antigen (PCNA) in 25 oral squamous cell carcinomas. PCNA-positive cells were detected in all formalin fixed, paraffin embedded specimens. The results were as follows: 1. The PCNA-positive rate in the group with cervical lymph node metastasis was significantly higher than in the group with no metastasis (p<0.05). 2. The PCNA-positive rate in the group with a clinical responce of no change was significantly higher than in the group with a partial response (p<0.01). 3. The PCNA-positive rate in specimens obtained during operation was significantly lower than those obtained by biopsy (p<0.05). These results suggests that the PCNA-positive rate may be a useful factor in selecting the most effective type of antitumor therapy. |
| Author | UTSUMI, Nobuo OHTA, Chikako OHNO, Jun SHIMADA, Jun YAMAMOTO, Yoshiro TAKESHIMA, Hiroshi OKITSU, Mitsuhisa FUKUNAGA, Shuichi NAGAMINE, Kouichiro |
| Author_xml | – sequence: 1 fullname: OHNO, Jun organization: Department of Oral Pathology, Meikai University School of Dentistry – sequence: 1 fullname: NAGAMINE, Kouichiro organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: OHTA, Chikako organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: TAKESHIMA, Hiroshi organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: SHIMADA, Jun organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: UTSUMI, Nobuo organization: Department of Oral Pathology, Meikai University School of Dentistry – sequence: 1 fullname: YAMAMOTO, Yoshiro organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: OKITSU, Mitsuhisa organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry – sequence: 1 fullname: FUKUNAGA, Shuichi organization: First Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry |
| BookMark | eNo9kE1PwzAMhiM0JMbYhV-QM1JHnDb9OKKJj0mTuMC5clN3S9UmI2kP_Hu6Fe1iW_bjV_Z7zxbWWWLsEcRGZUXy3LauD5sENnDDlhLyNIKpv2BLISRECtL4jq1DaIUQkCVSpsmS4a7vR-uOJgxOH6k3GjsehrE2FLhr-Mm7zjTkcTD2wDV1Hbej7gg9RzuYA1luLHf-vPUzYu_GMFMavTbW9fjAbhvsAq3_84p9v71-bT-i_ef7bvuyjzTkOUSUU5FmpLFWWmAMWZUWmoSIE6GaJoGqhmqqRVXIWmEOsZIil1KrWBeNKmS8Yk-zrvYuBE9NefKmR_9bgijP_pQXf8oESpjg7Qy3YcADXVH0g5m-m1GYDrrgc4DrVB_Rl2TjP4aUdQQ |
| ContentType | Journal Article |
| Copyright | Japanese Society of Oral and Maxillofacial Surgeons |
| Copyright_xml | – notice: Japanese Society of Oral and Maxillofacial Surgeons |
| DBID | AAYXX CITATION |
| DOI | 10.5794/jjoms.41.1 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2186-1579 |
| EndPage | 5 |
| ExternalDocumentID | 10_5794_jjoms_41_1 article_jjoms1967_41_1_41_1_1_article_char_en |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS F5P JSF KQ8 RJT AAYXX CITATION |
| ID | FETCH-LOGICAL-c1881-e8e967ecad5c0a317b69ce003405ff41bd1b3400b92d5a813520822c53c9f5923 |
| ISSN | 0021-5163 |
| IngestDate | Tue Jul 01 02:16:56 EDT 2025 Wed Sep 03 06:29:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1881-e8e967ecad5c0a317b69ce003405ff41bd1b3400b92d5a813520822c53c9f5923 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjoms1967/41/1/41_1_1/_article/-char/en |
| PageCount | 5 |
| ParticipantIDs | crossref_primary_10_5794_jjoms_41_1 jstage_primary_article_jjoms1967_41_1_41_1_1_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1995 |
| PublicationDateYYYYMMDD | 1995-01-01 |
| PublicationDate_xml | – year: 1995 text: 1995 |
| PublicationDecade | 1990 |
| PublicationTitle | Japanese Journal of Oral and Maxillofacial Surgery |
| PublicationTitleAlternate | Jpn. J. Oral. Maxillofac. Surg. |
| PublicationYear | 1995 |
| Publisher | Japanese Society of Oral and Maxillofacial Surgeons |
| Publisher_xml | – name: Japanese Society of Oral and Maxillofacial Surgeons |
| References | 2) Robbins, B. A., de la Vega, D., et al.: Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies. Arch Pathol Lab Med 111: 841-845 1987. 11) 山本悦秀, 宮川明, 他: 口腔粘膜癌の所属リンパ節内浸潤像に関する研究. 日口外誌30: 1824-1833 1984. 7) 島袋智之, 和田尚, 他: 抗PCNA抗体を用いた増殖細胞検出法の基礎的検討. Cytometry Res2: 18-23 1992. 1) Matsumura, K., Tsuji, T., et al.: Immunohistochemical determination of growth fraction in human tumors. Path Res Pract 184: 609-613 1989. 3) 田中一成: 抗PCNA抗体による増殖細胞核の染色-パラフィン切片への応用-. 病理と臨床9: 791-798 1991. 5) Bravo, R., Frank, R., et al: Cyclin/PCNA is the auxiliary protein of DNA polymerase delta. Nature 326: 515-517 1987. 9) 岡本学, 大関悟, 他: 口腔癌における頸部郭清術施行例の検討-頸部リンパ節転移様相と予後-. 日口外誌31: 554-562 1985. 8) 松野吉宏, 向井清: 増殖細胞核抗原 (PCNA). 病理と臨床9: 879-883 1991. 10) 矢島幹人, 峯村俊一, 他: 口腔扁平上皮癌における頸部郭清術施行例の臨床統計的検討. 日口外誌35: 647-654 1989. 12) 佐藤明, 斉藤徹, 他: 舌扁平上皮癌における各種パラメータと原発部再発およびリンパ節転移との関連について. 日口外誌40: 717-722 1994. 4) 前田寛治, 辻龍雄, 他: 口腔扁平上皮癌におけるモノクローナル抗PCNA抗体による細胞動態の解析とその意義について. 日口外誌37: 1961-1965 1991. 6) Wassem, N. H. and Lane, D. P.: Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA): structural conservation and the detection of a nucleolar form. J cell Sci 96: 121-129 1990. |
| References_xml | – reference: 4) 前田寛治, 辻龍雄, 他: 口腔扁平上皮癌におけるモノクローナル抗PCNA抗体による細胞動態の解析とその意義について. 日口外誌37: 1961-1965 1991. – reference: 1) Matsumura, K., Tsuji, T., et al.: Immunohistochemical determination of growth fraction in human tumors. Path Res Pract 184: 609-613 1989. – reference: 5) Bravo, R., Frank, R., et al: Cyclin/PCNA is the auxiliary protein of DNA polymerase delta. Nature 326: 515-517 1987. – reference: 3) 田中一成: 抗PCNA抗体による増殖細胞核の染色-パラフィン切片への応用-. 病理と臨床9: 791-798 1991. – reference: 11) 山本悦秀, 宮川明, 他: 口腔粘膜癌の所属リンパ節内浸潤像に関する研究. 日口外誌30: 1824-1833 1984. – reference: 6) Wassem, N. H. and Lane, D. P.: Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA): structural conservation and the detection of a nucleolar form. J cell Sci 96: 121-129 1990. – reference: 8) 松野吉宏, 向井清: 増殖細胞核抗原 (PCNA). 病理と臨床9: 879-883 1991. – reference: 12) 佐藤明, 斉藤徹, 他: 舌扁平上皮癌における各種パラメータと原発部再発およびリンパ節転移との関連について. 日口外誌40: 717-722 1994. – reference: 9) 岡本学, 大関悟, 他: 口腔癌における頸部郭清術施行例の検討-頸部リンパ節転移様相と予後-. 日口外誌31: 554-562 1985. – reference: 7) 島袋智之, 和田尚, 他: 抗PCNA抗体を用いた増殖細胞検出法の基礎的検討. Cytometry Res2: 18-23 1992. – reference: 2) Robbins, B. A., de la Vega, D., et al.: Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies. Arch Pathol Lab Med 111: 841-845 1987. – reference: 10) 矢島幹人, 峯村俊一, 他: 口腔扁平上皮癌における頸部郭清術施行例の臨床統計的検討. 日口外誌35: 647-654 1989. |
| SSID | ssj0001742264 |
| Score | 1.3494747 |
| Snippet | We immunohistochemically studied proliferating cell nuclear antigen (PCNA) in 25 oral squamous cell carcinomas. PCNA-positive cells were detected in all... |
| SourceID | crossref jstage |
| SourceType | Index Database Publisher |
| StartPage | 1 |
| SubjectTerms | immunohistochemistry lymph node metastasis oral squamous cell carcinoma proliferating cell nuclear antigen |
| Title | Immunohistochemical studies of proliferating cell nuclear antigen in oral squamous cell carcinoma |
| URI | https://www.jstage.jst.go.jp/article/jjoms1967/41/1/41_1_1/_article/-char/en |
| Volume | 41 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Japanese Journal of Oral and Maxillofacial Surgery, 1995/01/20, Vol.41(1), pp.1-5 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaqhQMXBALE8pIluFUpcTbOQ-JSIbYt0XaFaKW9VbZjq9lqE9gml_0D_G1m7CRtoYeFixW5tpNmvs6r8yDkgzqTJvAl8yTzpRdyGXlJkGov0FLm3MRgsqCheDGPpsvw6xW_Ggx-7UUtNbUcqbujeSX_Q1WYA7piluw_ULY_FCbgGugLI1AYxnvReIbJHZUtGay6xP-tCwy0kczYkcdg1WSbWYteuhLLFwuMm6yxDCd6O2yK_vZnI9AJ4FYpbDBUVi3LblXXebEGpGTVphlO9EYMJ2KzEcXwDrTvddH7lMeT8cVsbkMss6op1Lq4rXpHbjZbfF-6YP1628Bz9zLhcjq_dEkiPVjPl9kSj7P-2bU9aueiwJTvfYYbMI-zlodpO4ddsDzGXQ-Zjgm76lcHYHMcle2JZn6M58NBIfL86-pmOwrZiO0kW_dv_h8Crw9DBAMId6_s3lXIVmBGPwjimGFsaPYt2TnrYptw7MKF3BdypW5x-8fdrQ-Um4fXoN93sYFWXVk8IY9bO4OOHWiekoEunxFxBDC0BQytDD0ADEUo0BYwtAUMLUqKgKEdYNyqHjDPyfL8y-Lz1Gt7bHiKJQnzdKLTKNZK5Fz5ApRJGaVKY9UinxsTMpkzCde-TIOci4SBvo49AhQ_U6nhYB28ICdlVeqXhBqjuFEiCHOdhkInacxiw6TmvknzSCan5H33clY_XCmV1d8UOCWf3Hvr17Q_L7cGBEZs17mB9Z9ikiLwhFf3uslr8siVJkBX2htyUt82-i0ol7V8Zwn_G2E3g3o |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunohistochemical+studies+of+proliferating+cell+nuclear+antigen+in+oral+squamous+cell+carcinoma&rft.jtitle=Nihon+Koku+Geka+Gakkai+zasshi&rft.au=NAGAMINE%2C+Kouichiro&rft.au=OKITSU%2C+Mitsuhisa&rft.au=OHNO%2C+Jun&rft.au=FUKUNAGA%2C+Shuichi&rft.date=1995&rft.issn=0021-5163&rft.eissn=2186-1579&rft.volume=41&rft.issue=1&rft.spage=1&rft.epage=5&rft_id=info:doi/10.5794%2Fjjoms.41.1&rft.externalDBID=n%2Fa&rft.externalDocID=10_5794_jjoms_41_1 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-5163&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-5163&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-5163&client=summon |