Immunohistochemical studies of proliferating cell nuclear antigen in oral squamous cell carcinoma

• Published in: Japanese Journal of Oral and Maxillofacial Surgery Vol. 41; no. 1; pp. 1 - 5
• Main Authors: OHNO, Jun, NAGAMINE, Kouichiro, OHTA, Chikako, TAKESHIMA, Hiroshi, SHIMADA, Jun, UTSUMI, Nobuo, YAMAMOTO, Yoshiro, OKITSU, Mitsuhisa, FUKUNAGA, Shuichi
• Format: Journal Article
• Language: English
• Published: Japanese Society of Oral and Maxillofacial Surgeons 1995
• Subjects: immunohistochemistry; lymph node metastasis; oral squamous cell carcinoma; proliferating cell nuclear antigen
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.41.1

We immunohistochemically studied proliferating cell nuclear antigen (PCNA) in 25 oral squamous cell carcinomas. PCNA-positive cells were detected in all formalin fixed, paraffin embedded specimens. The results were as follows: 1. The PCNA-positive rate in the group with cervical lymph node metastasis was significantly higher than in the group with no metastasis (p<0.05). 2. The PCNA-positive rate in the group with a clinical responce of no change was significantly higher than in the group with a partial response (p<0.01). 3. The PCNA-positive rate in specimens obtained during operation was significantly lower than those obtained by biopsy (p<0.05). These results suggests that the PCNA-positive rate may be a useful factor in selecting the most effective type of antitumor therapy.