Role of Common bla OXA-24/OXA-40 -Carrying Platforms and Plasmids in the Spread of OXA-24/OXA-40 among Acinetobacter Species Clinical Isolates

ABSTRACT The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla OXA-24/40 -carrying plasmids and genetic environments were characterized i...

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Published inAntimicrobial agents and chemotherapy Vol. 56; no. 7; pp. 3969 - 3972
Main Authors Grosso, Filipa, Quinteira, Sandra, Poirel, Laurent, Novais, Ângela, Peixe, Luísa
Format Journal Article
LanguageEnglish
Published 01.07.2012
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Summary:ABSTRACT The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla OXA-24/40 -carrying plasmids and genetic environments were characterized in representative ( n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla OXA-24/40 within the chromosomes of some isolates, the circulation of common bla OXA-24/40 -carrying plasmids (30-kb repA_AB ; 10-kb aci2 ) and genetic backbones among Acinetobacter spp. was demonstrated.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.06255-11