Mechanisms Underlying the Effects of Salicylic Acid and Its Salts on Helix Neurons Proceedings of V Congress of the Ukrainian Neuroscience Society (Kyiv, June 6-10, 2011)

In experiments on Helix neurons, we found that calcium is not involved in the neurotropic effects of salicylic acid and cobalt and zinc salicylates. This conclusion is based on the fact that the addition of BaCl 2 to the applied solutions of salicylates did not change the effects of the latter. Extr...

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Bibliographic Details
Published inNeurophysiology (New York) Vol. 44; no. 2; pp. 153 - 156
Main Authors Cheretayev, I. V., Korenyuk, I. I., Khusainov, D. R., Katyushina, O. V., Gamma, T. V., Kolotilova, O. I.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2012
Subjects
Biomedical and Life Sciences
Biomedicine
Indexing in process
Neurosciences
salicylates
salicylic acid
molluscan neurons
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Summary:In experiments on Helix neurons, we found that calcium is not involved in the neurotropic effects of salicylic acid and cobalt and zinc salicylates. This conclusion is based on the fact that the addition of BaCl 2 to the applied solutions of salicylates did not change the effects of the latter. Extracellular application of adenosine triphosphate (ATP) significantly modified the effects of salicylic acid and its salts. We believe that the inhibitory effect of salicylic acid on Helix neurons depends on the ability of salicylic acid to suppress ATP synthesis, while the activating effect of cobalt and zinc salicylates on neurons is related to the opposite effects of these salts on ATP synthesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-012-9282-0