Effect of Ubiquinone Q10 and Antioxidant Vitamins on Free Radical Oxidation of Phospholipids in Biological Membranes of Rat Liver

• Published in: Bulletin of experimental biology and medicine Vol. 140; no. 2; pp. 181 - 183
• Main Authors: Tikhaze, A. K., Konovalova, G. G., Lankin, V. Z., Kaminnyi, A. I., Kaminnaja, V. I., Ruuge, E. K., Kukharchuk, V. V.
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.08.2005
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-005-0439-3

We studied the effects of 30-day peroral treatment with β-carotene, a complex of antioxidant vitamins (vitamins C and E and provitamin A) and selenium, and solubilized ubiquinone Q10 on the antioxidant potential in rat liver (ascorbate-dependent free radical oxidation of unsaturated membrane phospholipids). β-Carotene irrespective of the administration route increased antioxidant potential of the liver by 2-3.5 times. The complex of antioxidant vitamins and selenium increased this parameter by more than 15 times. Antiradical activity in rat liver was extremely high after administration of solubilized ubiquinone Q 10 (increase by more than by 36 times). It can be expected that reduced ubiquinone Q10in vivo should produce a more pronounced protective effect due to activity of the system for bioregeneration of this natural antioxidant.